We get a lot of questions about fuel metering changes required for oxygenated fuels... and that is a good thing, because racers should be asking those questions.
Luckily, the answer is not necessarily complicated.
Let’s look at Sunoco EXO2 for instance. It’s a good fuel to use as an example because it contains 10% (by weight) oxygen. Without proper fuel enrichment, you won’t find the power you’re hoping for, and in fact the engine may not even run well.